Executive Director, Medical Affairs Managed Markets Team Lead

Location: Waltham
Posted on: June 23, 2025

Job Description:

Company Overview: Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. Role Summary: The Executive Director, Medical Affairs Managed Markets Team Lead leads Dyne Therapeutics' efforts in establishing and enhancing the value proposition of our products. This individual provides U.S. Medical Affairs strategic leadership with National, Regional and Government payers. This individual ensures the successful integration and communication of disease state, clinical, health economics, and outcomes research information and data strategies. This position manages scientific discussions and provides clinical insights to payors, enhancing the understanding of Dyne’s innovative therapies and their value proposition. The role focuses on creating and communicating the scientific and clinical value of Dyne's portfolio to payers, health authorities, and other external stakeholders, while ensuring alignment with the company’s objectives. This leader serves as a key partner across the organization, collaborating closely with clinical development, field medical, regulatory affairs, commercial, and other functions to maximize the medical value of Dyne's therapies. This role also plays a critical role in managing the Managed Markets team and driving cross-functional alignment in the execution of payer-focused initiatives underpinned by scientifically accurate information. The Executive Director will build and lead a team of Payor MSLs focused on delivering high-quality medical information and fostering collaborations that support access and reimbursement. Primary Responsibilities Include: Develop and implement a comprehensive payor-focused MSL strategy that aligns with Dyne Therapeutics’ overall business objectives and product portfolio Build, grow and lead the Managed Markets (MM) team, providing strategic direction and ensuring the integration of disease state, clinical, economic, and quality of life evidence to deliver clear, compelling product value propositions Lead development and presentation of payer-facing content, based in factual disease state and Dyne program data, that allows informed payer decision-making on coverage of Dyne products Lead a team of MSLs in engaging with payors, advocating for the scientific and clinical value of Dyne's therapies through strong scientific dialogue and presentation of relevant data Ensure accurate, timely, and effective communication of clinical data and product information to payors, including health technology assessment organizations and decision-makers Partner with Medical Affairs, Clinical Development, Regulatory Affairs, and Commercial teams to ensure alignment on the scientific and economic data required for market access and reimbursement Represent the Managed Markets function in key internal and external meetings, including interactions with payers, health systems, and policy makers to optimize reimbursement strategies and ensure alignment with market needs Provide leadership and mentorship to a high-performing team, fostering a culture of collaboration, accountability, and innovation Lead the co-development of payer evidence dossiers and value communication strategies for Dyne's therapies Analyze the payor landscape to gather insights on market access barriers and developments, informing internal strategies and ensuring responsiveness to evolving payor needs Maintain a deep understanding of the evolving landscape of neuromuscular/rare disease treatments, including payer requirements and data needs, and bring these needs back to program and development teams to action Collaborate with Medical Affairs/Clinical Development, HEOR to ensure the integration of real-world evidence (RWE) and clinical trial data into the value proposition Provide training and ongoing support to MSL team members and other internal stakeholders on payor-related topics, clinical data interpretation, and communication strategies Drive execution of field medical strategic plans, delivering on a strong portfolio-wide value proposition to our external stakeholders and population health decision makers (PHDMs) outcomes Ensure all activities comply with industry regulations and internal policies, maintaining the highest ethical standards in all interactions with stakeholders Mentor and develop a high-performing team of payor MSLs, fostering an environment of collaboration, innovation, and excellence Education and Skills Requirements: Core Competencies: Strong comprehension of investigational products and a solid understanding of the neuromuscular space, including new data as it becomes available Comprehensive understanding of the clinical trial and investigator-sponsored study processes Demonstrated ability to work effectively on multi-disciplinary teams to achieve desired outcomes Exceptional communication and leadership skills with the ability to influence both internal and external stakeholders. Highly collaborative and capable of leading diverse, cross-functional teams in a fast-paced environment. Ability to comprehend and communicate research results across diverse audiences Demonstrate professional communications (written, verbal, presentation, and listening) to cultivate and nurture strong working relationships with internal and external colleagues Expert level skills to plan, prioritize, and execute multiple responsibilities in a timely manner Ability to work independently, within a home office while efficiently managing time and priorities Ability to operate with ambiguity and thrive in an ever-changing environment. Must be willing to travel extensively and occasionally on weekends Results-oriented with a track record of delivering on objectives and driving impactful Qualifications: Advanced degree in life sciences (MD, PhD, PharmD) or equivalent experience in a biopharmaceutical or biotech setting A minimum of 15 years of experience in market access, health economics, or related roles, with significant experience in leadership and team management A minimum of 5-7 years of leadership experience leading field medical/payer teams. Proven expertise in developing value propositions, payer strategy, and outcomes research for biotech or pharmaceutical products, particularly in rare diseases or genetic therapies Demonstrated experience working cross-functionally with clinical, regulatory, and commercial teams Strong understanding of US payor landscape reimbursement models, pricing strategies, and health policy The pay range displayed below is the range of base pay compensation within which the company expects to pay for this role at the time of this posting. Individual compensation depends on a variety of factors, including, but not limited to, prior education and experience, job-related knowledge and demonstrated skills. Salary Range $299,000 - $329,000 USD The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Keywords: , Chicopee , Executive Director, Medical Affairs Managed Markets Team Lead, Science, Research & Development , Waltham, Massachusetts