Principal Scientist, Protein Design and Antibody Engineering

Location: Tarrytown
Posted on: June 23, 2025

Job Description:

We are seeking a highly skilled and motivated Principal Scientist with expertise in computational biology, protein structural modeling and engineering, and artificial intelligence to join the Bispecific Antibodies Group. This role focuses on designing and optimizing novel antibody therapeutics leveraging cutting-edge computational methods, structural modeling, and high-throughput experimental data. The ideal candidate will thrive in a multidisciplinary environment at the intersection of biology, computation, and automation. As a Principal Scientist in the Bispecifics Group, a typical day might include: Apply advanced protein structure prediction and molecular modeling techniques to guide antibody design and optimization. Develop and apply cutting-edge AI/machine learning models to support early-stage drug discovery projects. Support team efforts in implementing high-throughput screen platforms and automation systems for antibody discovery and optimization. Contribute to the Bispecific Groups pipeline of protein production and purification. Independently analyze data and deliver presentations at group, departmental and senior leadership meetings. Maintain accurate electronic records, prepare documents for regulatory filings, patent applications, and scientific publications. Stay up to date with the latest advances in AI-driven drug discovery, structural bioinformatics, and antibody engineering. This role may be for you if you: Are passionate about innovation and early-stage drug development. Are a team player and excel in a fast-paced, collaborative team environment. Possess excellent communication, organization, and time management skills. Can communicate results effectively to both technical and non-technical audiences. Can quickly adapt to changes and enjoy new challenges. Can manage multiple projects simultaneously with confidence. To be considered for this opportunity, you must have a Ph.D. in Biological Engineering, Computational Biology, Structural Biology, or a related field with 5 years of relevant academic or industry experience. You must have strong proficiency in programming languages (e.g., Python, R, and/or C++) and protein modeling software (e.g., Rosetta, AlphaFold). You should have deep understanding of protein structure and function. Knowledge of antibody structure and engineering is a plus. Familiarity with AI-assisted de novo protein design is required. Experience with high-throughput screening methods and data analysis from display technologies or next-generation sequencing is strongly preferred. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $126,700.00 - $206,900.00

Keywords: , Chicopee , Principal Scientist, Protein Design and Antibody Engineering, Science, Research & Development , Tarrytown, Massachusetts